I've been playing on Poker Room for about 5-6 months now, and I'd have to say that its software is the best I've come through.
The ring games for all of the games offered will often be weak and easy, and the only ones I haven't tried are Omaha Hi/Lo and Stud Hi/Lo.
The limit games are profitable for hold'em, and multi tabling shouldn't be a problem for anyone, especially with the easy to press fold/call/raise buttons.
7 card stud is just as good, though there are times when you'll want to kill some of the people you're playing with at the lower limits (but hey that happens everywhere).
5 card draw is also very profitable on this site, if one plays well!
The tournaments are pretty good, and it's always easy to find yourself a quick sit n' go. Promotions such as the centurion cup are good as well, though it's a shame they've cancelled the Royal Money promotion.
I have but few complaints about the site, basically the fact that the servers can sometimes be very slow, as well as being slow with putting money played with back into your account balance. It also wouldn't hurt to have more people sign up for the stud tournaments, it's usually no more than 30 people.